The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression

Dingcheng Gao, Vivek Mittal

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Emerging evidence from murine models suggests that tumor-specific endocrine factors systemically stimulate the quiescent bone marrow (BM) compartment, resulting in the expansion, mobilization and recruitment of BM progenitor cells. Discrete subsets of tumor-instigated BM-derived progenitor cells support tumor progression and metastasis by regulating angiogenesis, inflammation and immune suppression. Notably, clinical studies have begun to reveal that increased BM recruitment in tumors is associated with poor prognosis. Thus, the BM-derived tumor microenvironment is an attractive therapeutic target, and drugs targeting the components of the microenvironment are currently in clinical trials. Here, we focus on recent advances and emerging concepts regarding the intriguing role of BM-derived cells in tumor growth, metastasis initiation and progression, and we discuss future directions in the context of novel diagnostic and therapeutic opportunities.

Original languageEnglish (US)
Pages (from-to)333-343
Number of pages11
JournalTrends in Molecular Medicine
Volume15
Issue number8
DOIs
StatePublished - Aug 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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