The role of bariatric surgery in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Daniel Shouhed, Justin Steggerda, Miguel Burch, Mazen Noureddin

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Introduction: Nonalcoholic fatty liver disease (NAFLD) affects between 25% and 33% of the population, is more common in obese individuals, and is the most common cause of chronic liver disease in the United States. However, despite rising prevalence, effective treatments remain limited. Areas covered: We performed a literature search across multiple databases (Pubmed, Medline, etc.) to identify significant original research and review articles to provide an up-to-date and concise overview of disease pathogenesis and diagnostic evaluation and to expand on available treatment options with a specific focus on the potential role of bariatric surgery. Here we provide the most comprehensive review of bariatric surgery for the management of NAFLD, noting benefits from different procedures and multiple reports showing improvements in steatosis, inflammation and fibrosis over the duration of follow-up. Expert commentary: The morbidity of NAFLD is significant as it may become the most common indication for liver transplantation within the next 5 years. In addition to known benefits of weight loss and diabetes resolution, bariatric surgery has the potential to halt and reverse disease progression and future controlled trials should be performed to further define its benefit in the treatment of NAFLD in morbidly obese patients.

Original languageEnglish (US)
Pages (from-to)797-811
Number of pages15
JournalExpert Review of Gastroenterology and Hepatology
Volume11
Issue number9
DOIs
StatePublished - Sep 2 2017

Keywords

  • Bariatric surgery
  • fibrosis
  • liver biopsy
  • nonalcoholic fatty liver disease
  • nonalcoholic steatohepatitis
  • Roux-en-Y gastric bypass
  • steatosis
  • vertical sleeve gastrectomy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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