The role of B cell differentiation factors and specific T cell help in the pathogenesis of primary hypogammaglobulinemia

Malcolm Brenner, Margaret E. North, Hakikat R. Chadda, Christine A. Newton, Mirek Malkovsky, A. David B. Webster, John Farrant

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We have examined the function of T and B cells from patients with late onset primary acquired hypogammaglobulinemia (PHG). T cells from these patients give effective help to normal B cells for antigen-dependent antibody synthesis. PHG mononuclear cells also synthesize normal quantities of B cell differentiation factors, which enhance IgG, IgM and antigen-dependent antibody synthesis by normal lymphocytes. While patient T cells appear to behave appropriately, the responsiveness of patient B cells is abnormal. Although they respond to differentiation factors with increased synthesis of IgM, overall levels are 10-50-fold lower than normal B cells, and they produce little or no IgG. This pattern of response is not altered if normal T cells are the source of help. The poor response of the B cell appears to represent immaturity rather than an inherent defect, as IgG-secreting clones can be obtained after Epstein-Barr virus transformation of lymphocytes from certain patients, and some of these clones respond to differentiation factors with increased IgG production. The lack of any functional defect in the T population, and the apparent immaturity rather than abnormality of the B cells, may implicate accessory cells in the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)1021-1027
Number of pages7
JournalEuropean Journal of Immunology
Volume14
Issue number11
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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