The role of β-catenin in chronic myeloproliferative disorders

Monica P. Jauregui, Steven R. Sanchez, April A. Ewton, Lawrence Rice, Sherrie L. Perkins, Cherie H. Dunphy, Chung Che Chang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The goal of the current study is to evaluate the role of β-catenin in chronic myeloproliferative disorders. Expression of β-catenin was analyzed by immunohistochemistry in formalin-fixed decalcified bone marrow biopsy specimens from 52 chronic myeloproliferative disorder cases and 6 nonchronic myeloproliferative disorder bone marrows as controls. The frequency of moderate to strong β-catenin staining of megakaryocytes was significantly higher in polycythemia vera cases and in essential thrombocythemia cases than in chronic myelogenous leukemia cases (polycythemia vera versus chronic myelogenous leukemia, P = .002345, Fisher exact; and essential thrombocythemia versus chronic myelogenous leukemia, P = .002288), chronic idiopathic myelofibrosis cases (polycythemia vera versus chronic idiopathic myelofibrosis, P = .006707 and essential thrombocythemia versus chronic idiopathic myelofibrosis, P = .006932) or control cases (polycythemia vera versus control, P = .010489 and essential thrombocythemia versus control, P = .0113120). The erythroid and myeloid lineages showed absent to weak β-catenin staining in most cases. In conclusion, these results indicate that the Wnt/β-catenin signaling pathway may have a role in megakaryocytopoiesis in polycythemia vera and essential thrombocythemia. In addition, β-catenin may be a useful marker for differentiating polycythemia vera and essential thrombocythemia from other types of chronic myeloproliferative disorders.

Original languageEnglish (US)
Pages (from-to)1454-1458
Number of pages5
JournalHuman Pathology
Volume39
Issue number10
DOIs
StatePublished - Oct 2008

Keywords

  • β-catenin
  • Chronic myeloproliferative disorders
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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