The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver

Stefan Westin, Petra Tollet, Anders Ström, Agneta Mode, Jan Åke Gustafsson

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.

Original languageEnglish (US)
Pages (from-to)1045-1053
Number of pages9
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume43
Issue number8
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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