The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver

Stefan Westin; Petra Tollet; Anders Ström; Agneta Mode; Jan Åke Gustafsson

doi:10.1016/0960-0760(92)90332-D

The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver

Stefan Westin, Petra Tollet, Anders Ström, Agneta Mode, Jan Åke Gustafsson

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23 Scopus citations

Abstract

The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.

Original language	English (US)
Pages (from-to)	1045-1053
Number of pages	9
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	43
Issue number	8
DOIs	https://doi.org/10.1016/0960-0760(92)90332-D
State	Published - Dec 1992

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

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10.1016/0960-0760(92)90332-D

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title = "The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver",

abstract = "The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.",

author = "Stefan Westin and Petra Tollet and Anders Str{\"o}m and Agneta Mode and Gustafsson, {Jan {\AA}ke}",

note = "Funding Information: Acknowledgement--This work was supported by a grant from the Swedish Medical Research Council (No. 03X-06807). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1992",

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AU - Tollet, Petra

AU - Ström, Anders

AU - Mode, Agneta

AU - Gustafsson, Jan Åke

PY - 1992/12

Y1 - 1992/12

N2 - The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.

AB - The determination of sexually dimorphic hepatic steroid metabolism in rat liver has been shown to involve growth hormone. However, the mechanisms by which growth hormone controls the cytochrome P450 enzymes responsible for this dimorphic steroid metabolism is largely unknown. In this review we discuss different levels of growth hormone signal transduction, including receptor binding, signal transduction and activation of target genes by growth hormone.

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The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver

Abstract

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