The relationship of serum androgens and ovulatory status to blood pressure in reproductive-age women

C. Ayala, E. Steinberger, A. Sweeney, W. H. Mueller, D. K. Waller, R. Hardy, S. M. Petak, L. J. Rodriguez-Rigau, K. D. Smith

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The objective of this cross-sectional study was to determine the relationship between hyperandrogenemia and blood pressure in women with menstrual irregularities seen at an endocrinology clinic. Women with serum testosterone levels (T) ≥ 30 ng/dL were more likely to have general obesity (odds ratio [OR] = 6.8, 95% confidence intervals [CI] = 2.2-27.2) and central obesity (OR = 14.5, 95% CI = 6.1-38.7) than euandrogenemic women. Hyperandrogenemic women (HA) had an OR of 2.4 (95% CI = 1.0-6.2) for elevated SBP and an OR of 2.7 (95% CI = 0.8-8.8) for elevated DBP, independent of age and ovulatory status. Obese HA had an OR of 4.7 (95% CI = 2.3-10.4) for elevated SBP and an OR of 2.9 (95% CI = 1.9-9.9) for elevated DBP. In conclusion, T is associated with an increased risk for obesity and central adiposity. T predicts BP elevation independent of age and ovulatory status. There was a synergistic relationship between obesity and androgens in their affect on BP.

Original languageEnglish (US)
Pages (from-to)772-777
Number of pages6
JournalAmerican Journal of Hypertension
Volume12
Issue number8 I
DOIs
StatePublished - 1999

Keywords

  • Adiposity
  • Androgens
  • Blood pressure
  • Hyperandrogenemia
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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