The recommendations of Chinese Parkinson's disease and movement disorder society consensus on therapeutic management of Parkinson's disease

Shengdi Chen, Piu Chan, Shenggang Sun, Haibo Chen, Baorong Zhang, Weidong Le, Chunfeng Liu, Guoguang Peng, Beisha Tang, Lijuan Wang, Yan Cheng, Ming Shao, Zhenguo Liu, Zhenfu Wang, Xiaochun Chen, Mingwei Wang, Xinhua Wan, Huifang Shang, Yiming Liu, Pingyi XuJian Wang, Tao Feng, Xianwen Chen, Xingyue Hu, Anmu Xie, Qin Xiao

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Background: Parkinson's disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia and postural instability. As the disease progresses, additional complications can arise such as non-motor and neurobehavioral symptoms. Pharmacological treatment and surgical intervention for PD have been implemented in China. Until 10 years ago, there was lack of standardization for the management of PD in different regions and among different physicians, leading to different treatment levels in different regions and different physicians. Since then, the Chinese Parkinson's Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China, in 2006, 2009 and 2014, respectively. Correspondingly, the overall level of treatment for PD in China improved. Objectives: To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence, and to improve the treatment options available to physicians in the management of PD. Summary: A variety of treatment recommendations in the treatment guidelines have been proposed, including physical activity and disease-modifying medication, which should be initiated at the early-stage of the disease. The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs, to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications. Moreover, different treatment strategies should be considered at different stages of the disease. Importantly, treatment guidelines and personalized treatments should be valued equally. A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China.

Original languageEnglish (US)
Article number12
JournalTranslational Neurodegeneration
Volume5
Issue number1
DOIs
StatePublished - Jun 30 2016

Keywords

  • Parkinson's disease
  • Treatment guideline, optimal therapeutic options, China

ASJC Scopus subject areas

  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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