The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journalReview articlepeer-review


Soft tissue tumors are rare mesenchymal tumors with divergent differentiation. The diagnosis of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and histological overlap among the tumor entities. Present-day understanding of the molecular pathogenesis of soft tissue tumors has rapidly increased with the development of molecular genetic techniques (e.g., next-generation sequencing). Additionally, immunohistochemical markers that serve as surrogate markers for recurrent translocations in soft tissue tumors have been developed. This review aims to provide an update on recently described molecular findings and relevant novel immunohistochemical markers in selected soft tissue tumors.

Original languageEnglish (US)
Article number5934
JournalInternational journal of molecular sciences
Issue number6
StatePublished - Mar 21 2023


  • immunohistochemistry
  • molecular pathology
  • sarcoma
  • soft tissue tumor
  • translocation
  • Sarcoma/pathology
  • Translocation, Genetic
  • Diagnosis, Differential
  • Soft Tissue Neoplasms/diagnosis
  • Humans
  • In Situ Hybridization, Fluorescence
  • Biomarkers, Tumor/genetics

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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