The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors

Joon Hyuk Choi; Jae Y. Ro

doi:10.3390/ijms24065934

The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Soft tissue tumors are rare mesenchymal tumors with divergent differentiation. The diagnosis of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and histological overlap among the tumor entities. Present-day understanding of the molecular pathogenesis of soft tissue tumors has rapidly increased with the development of molecular genetic techniques (e.g., next-generation sequencing). Additionally, immunohistochemical markers that serve as surrogate markers for recurrent translocations in soft tissue tumors have been developed. This review aims to provide an update on recently described molecular findings and relevant novel immunohistochemical markers in selected soft tissue tumors.

Original language	English (US)
Article number	5934
Journal	International journal of molecular sciences
Volume	24
Issue number	6
DOIs	https://doi.org/10.3390/ijms24065934
State	Published - Mar 21 2023

Keywords

immunohistochemistry
molecular pathology
sarcoma
soft tissue tumor
translocation
Sarcoma/pathology
Translocation, Genetic
Diagnosis, Differential
Soft Tissue Neoplasms/diagnosis
Humans
In Situ Hybridization, Fluorescence
Biomarkers, Tumor/genetics

ASJC Scopus subject areas

Molecular Biology
Spectroscopy
Catalysis
Inorganic Chemistry
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/ijms24065934

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title = "The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors",

abstract = "Soft tissue tumors are rare mesenchymal tumors with divergent differentiation. The diagnosis of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and histological overlap among the tumor entities. Present-day understanding of the molecular pathogenesis of soft tissue tumors has rapidly increased with the development of molecular genetic techniques (e.g., next-generation sequencing). Additionally, immunohistochemical markers that serve as surrogate markers for recurrent translocations in soft tissue tumors have been developed. This review aims to provide an update on recently described molecular findings and relevant novel immunohistochemical markers in selected soft tissue tumors.",

keywords = "immunohistochemistry, molecular pathology, sarcoma, soft tissue tumor, translocation, Sarcoma/pathology, Translocation, Genetic, Diagnosis, Differential, Soft Tissue Neoplasms/diagnosis, Humans, In Situ Hybridization, Fluorescence, Biomarkers, Tumor/genetics",

author = "Choi, {Joon Hyuk} and Ro, {Jae Y.}",

note = "Funding Information: This work was supported by the 2022 Yeungnam University Research Grant. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

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doi = "10.3390/ijms24065934",

language = "English (US)",

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AU - Ro, Jae Y.

PY - 2023/3/21

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N2 - Soft tissue tumors are rare mesenchymal tumors with divergent differentiation. The diagnosis of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and histological overlap among the tumor entities. Present-day understanding of the molecular pathogenesis of soft tissue tumors has rapidly increased with the development of molecular genetic techniques (e.g., next-generation sequencing). Additionally, immunohistochemical markers that serve as surrogate markers for recurrent translocations in soft tissue tumors have been developed. This review aims to provide an update on recently described molecular findings and relevant novel immunohistochemical markers in selected soft tissue tumors.

AB - Soft tissue tumors are rare mesenchymal tumors with divergent differentiation. The diagnosis of soft tissue tumors is challenging for pathologists owing to the diversity of tumor types and histological overlap among the tumor entities. Present-day understanding of the molecular pathogenesis of soft tissue tumors has rapidly increased with the development of molecular genetic techniques (e.g., next-generation sequencing). Additionally, immunohistochemical markers that serve as surrogate markers for recurrent translocations in soft tissue tumors have been developed. This review aims to provide an update on recently described molecular findings and relevant novel immunohistochemical markers in selected soft tissue tumors.

KW - immunohistochemistry

KW - molecular pathology

KW - sarcoma

KW - soft tissue tumor

KW - translocation

KW - Sarcoma/pathology

KW - Translocation, Genetic

KW - Diagnosis, Differential

KW - Soft Tissue Neoplasms/diagnosis

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Biomarkers, Tumor/genetics

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DO - 10.3390/ijms24065934

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The Recent Advances in Molecular Diagnosis of Soft Tissue Tumors

Abstract

Keywords

ASJC Scopus subject areas

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