The pursuit of cryptococcal pathogenesis: Heterologous hosts and the study of cryptococcal host-pathogen interactions

Roanna London; Benjamin Samuel Orozco; Eleftherios Mylonakis

doi:10.1111/j.1567-1364.2006.00056.x

The pursuit of cryptococcal pathogenesis: Heterologous hosts and the study of cryptococcal host-pathogen interactions

Roanna London, Benjamin Samuel Orozco, Eleftherios Mylonakis

Research output: Contribution to journal › Short survey › peer-review

27 Scopus citations

Abstract

Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens with invertebrates, such as Acanthamoeba castellanii, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster and Galleria mellonella. The study of host-pathogen interactions using these model hosts has allowed rapid screening of mutant libraries and can be used for the study of evolutionarily preserved aspects of microbial virulence and host response.

Original language	English (US)
Pages (from-to)	567-573
Number of pages	7
Journal	FEMS Yeast Research
Volume	6
Issue number	4
DOIs	https://doi.org/10.1111/j.1567-1364.2006.00056.x
State	Published - Jun 2006

Keywords

Caenorhabditis elegans
Cryptococcus neoformans
Drosophila melanogaster
Fungal infection
Galleria mellonella
Toll-pathway

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

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10.1111/j.1567-1364.2006.00056.x

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title = "The pursuit of cryptococcal pathogenesis: Heterologous hosts and the study of cryptococcal host-pathogen interactions",

abstract = "Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens with invertebrates, such as Acanthamoeba castellanii, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster and Galleria mellonella. The study of host-pathogen interactions using these model hosts has allowed rapid screening of mutant libraries and can be used for the study of evolutionarily preserved aspects of microbial virulence and host response.",

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AU - Orozco, Benjamin Samuel

AU - Mylonakis, Eleftherios

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AB - Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens with invertebrates, such as Acanthamoeba castellanii, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster and Galleria mellonella. The study of host-pathogen interactions using these model hosts has allowed rapid screening of mutant libraries and can be used for the study of evolutionarily preserved aspects of microbial virulence and host response.

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KW - Drosophila melanogaster

KW - Fungal infection

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The pursuit of cryptococcal pathogenesis: Heterologous hosts and the study of cryptococcal host-pathogen interactions

Abstract

Keywords

ASJC Scopus subject areas

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