The promise of comparative genomics in mammals

Stephen J. O'Brien, Marilyn Menotti-Raymond, William J. Murphy, William G. Nash, Johannes Wienberg, Roscoe Stanyon, Neal G. Copeland, Nancy A. Jenkins, James E. Womack, Jennifer A. Marshall Graves

Research output: Contribution to journalReview article

377 Scopus citations

Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate- resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

Original languageEnglish (US)
Pages (from-to)458-463
Number of pages6
JournalScience
Volume286
Issue number5439
DOIs
StatePublished - Oct 15 1999

ASJC Scopus subject areas

  • General

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