TY - JOUR
T1 - The POINTER Imaging baseline cohort
T2 - Associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition
AU - for the U.S. POINTER Study Group
AU - Harrison, Theresa M.
AU - Ward, Tyler
AU - Taggett, Jacinda
AU - Maillard, Pauline
AU - Lockhart, Samuel N.
AU - Jung, Youngkyoo
AU - Lovato, Laura C.
AU - Koeppe, Robert
AU - Jagust, William J.
AU - Harvey, Danielle
AU - Masdeu, Joseph C.
AU - Oh, Hwamee
AU - Gitelman, Darren R.
AU - Aggarwal, Neelum T.
AU - Espeland, Mark A.
AU - Cleveland, Maryjo L.
AU - Whitmer, Rachel
AU - Farias, Sarah Tomaszewski
AU - Salloway, Stephen
AU - Pavlik, Valory
AU - Yu, Melissa
AU - Tangney, Christine
AU - Snyder, Heather
AU - Carrillo, Maria
AU - Baker, Laura D.
AU - Vemuri, Prashanthi
AU - DeCarli, Charles
AU - Landau, Susan M.
N1 - Publisher Copyright:
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2025/1
Y1 - 2025/1
N2 - INTRODUCTION: The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is evaluating lifestyle interventions in older adults at risk for cognitive decline and dementia. Here we characterize the baseline data set of the POINTER Imaging ancillary study. METHODS: Participants underwent health and cognitive assessments and neuroimaging with multimodal positron emission tomography (PET) (beta-amyloid [Aβ] and tau) and magnetic resonance imaging (MRI). Framingham risk score (FRS) was used to quantify cardiovascular disease (CVD) risk. RESULTS: A total of 1052 participants (31% from underrepresented ethnoracial groups) were enrolled. Compared to Aβ−, Aβ+ (29%) participants were older, had higher apolipoprotein E (APOE) ε4 carriage rate and white matter hyperintensity volume, and greater temporal tau. FRS was related to MRI measures, but not AD biomarkers. FRS and tau had independent effects on cognition. DISCUSSION: In this heterogenous, at-risk cohort, CVD risk was related to more abnormal brain structure and poorer cognition, representing a putative non-AD (Alzheimer's disease) pathway to brain injury and cognitive decline. Highlights: ·The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) cohort is enriched for cardiovascular disease (CVD) and poor lifestyle ·POINTER Imaging collected multimodal neuroimaging data in this unique, at-risk cohort ·Amyloid burden was related to age, apolipoprotein E (APOE) ε4 carriage, and measures of disease progression ·Associations between amyloid and tau, and tau and cognition, were relatively weak ·CVD risk and tau pathology were independently related to memory.
AB - INTRODUCTION: The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is evaluating lifestyle interventions in older adults at risk for cognitive decline and dementia. Here we characterize the baseline data set of the POINTER Imaging ancillary study. METHODS: Participants underwent health and cognitive assessments and neuroimaging with multimodal positron emission tomography (PET) (beta-amyloid [Aβ] and tau) and magnetic resonance imaging (MRI). Framingham risk score (FRS) was used to quantify cardiovascular disease (CVD) risk. RESULTS: A total of 1052 participants (31% from underrepresented ethnoracial groups) were enrolled. Compared to Aβ−, Aβ+ (29%) participants were older, had higher apolipoprotein E (APOE) ε4 carriage rate and white matter hyperintensity volume, and greater temporal tau. FRS was related to MRI measures, but not AD biomarkers. FRS and tau had independent effects on cognition. DISCUSSION: In this heterogenous, at-risk cohort, CVD risk was related to more abnormal brain structure and poorer cognition, representing a putative non-AD (Alzheimer's disease) pathway to brain injury and cognitive decline. Highlights: ·The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) cohort is enriched for cardiovascular disease (CVD) and poor lifestyle ·POINTER Imaging collected multimodal neuroimaging data in this unique, at-risk cohort ·Amyloid burden was related to age, apolipoprotein E (APOE) ε4 carriage, and measures of disease progression ·Associations between amyloid and tau, and tau and cognition, were relatively weak ·CVD risk and tau pathology were independently related to memory.
KW - Framingham risk score
KW - MRI
KW - PET
KW - amyloid
KW - cerebrovascular injury
KW - memory
KW - minoritized groups
KW - preclinical Alzheimer's disease
KW - tau
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UR - http://www.scopus.com/inward/citedby.url?scp=85211577644&partnerID=8YFLogxK
U2 - 10.1002/alz.14399
DO - 10.1002/alz.14399
M3 - Article
AN - SCOPUS:85211577644
SN - 1552-5260
VL - 21
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 1
M1 - e14399
ER -