The Pathophysiology of Uremia

Tariq Shafi, Eugene P. Rhee

Research output: Chapter in Book/Report/Conference proceedingChapter


Uremia is a clinical syndrome with a wide range of signs and symptoms. It arises with advanced kidney failure and is characterized by the accumulation of numerous organic chemicals that would normally be cleared by healthy kidneys. Despite an ever-expending catalog of retained chemicals, or uremic solutes, a fundamental understanding of the fundamental cause(s) of uremia remains elusive.

Original languageEnglish (US)
Title of host publicationChronic Kidney Disease, Dialysis, and Transplantation
Subtitle of host publicationA Companion to Brenner and Rector’s The Kidney
ISBN (Electronic)9780323529785
StatePublished - Jan 1 2018


  • ADMA
  • ESRD
  • Indoxyl sulfate
  • Metabolomics
  • Microbiome
  • P-cresol sulfate
  • TMAO
  • Uremia
  • Uremic solute
  • Uremic toxin

ASJC Scopus subject areas

  • Medicine(all)


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