The Pathophysiology of Uremia

Tariq Shafi; Eugene P. Rhee

doi:10.1016/B978-0-323-52978-5.00018-5

The Pathophysiology of Uremia

Tariq Shafi, Eugene P. Rhee

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Uremia is a clinical syndrome with a wide range of signs and symptoms. It arises with advanced kidney failure and is characterized by the accumulation of numerous organic chemicals that would normally be cleared by healthy kidneys. Despite an ever-expending catalog of retained chemicals, or uremic solutes, a fundamental understanding of the fundamental cause(s) of uremia remains elusive.

Original language	English (US)
Title of host publication	Chronic Kidney Disease, Dialysis, and Transplantation
Subtitle of host publication	A Companion to Brenner and Rector’s The Kidney
Publisher	Elsevier
Pages	273-285.e5
ISBN (Electronic)	9780323529785
DOIs	https://doi.org/10.1016/B978-0-323-52978-5.00018-5
State	Published - Jan 1 2018

Keywords

ADMA
ESRD
Indoxyl sulfate
Metabolomics
Microbiome
P-cresol sulfate
TMAO
Uremia
Uremic solute
Uremic toxin

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-323-52978-5.00018-5

Cite this

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title = "The Pathophysiology of Uremia",

abstract = "Uremia is a clinical syndrome with a wide range of signs and symptoms. It arises with advanced kidney failure and is characterized by the accumulation of numerous organic chemicals that would normally be cleared by healthy kidneys. Despite an ever-expending catalog of retained chemicals, or uremic solutes, a fundamental understanding of the fundamental cause(s) of uremia remains elusive.",

keywords = "ADMA, ESRD, Indoxyl sulfate, Metabolomics, Microbiome, P-cresol sulfate, TMAO, Uremia, Uremic solute, Uremic toxin",

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AB - Uremia is a clinical syndrome with a wide range of signs and symptoms. It arises with advanced kidney failure and is characterized by the accumulation of numerous organic chemicals that would normally be cleared by healthy kidneys. Despite an ever-expending catalog of retained chemicals, or uremic solutes, a fundamental understanding of the fundamental cause(s) of uremia remains elusive.

KW - ADMA

KW - ESRD

KW - Indoxyl sulfate

KW - Metabolomics

KW - Microbiome

KW - P-cresol sulfate

KW - TMAO

KW - Uremia

KW - Uremic solute

KW - Uremic toxin

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SP - 273-285.e5

BT - Chronic Kidney Disease, Dialysis, and Transplantation

PB - Elsevier

ER -

The Pathophysiology of Uremia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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