The Parathyroid Gland and Heart Disease

Spandana J. Brown, Mary D. Ruppe, Laila S. Tabatabai

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Patients with disorders of the parathyroid gland have higher incidences of hypertension, arrhythmias, left ventricular hypertrophy, heart failure, and calcific disease which translate into increased cardiac morbidity and mortality. Importantly, clinical research also suggests that early treatment of parathyroid disorders through medical or surgical management may reverse cardiovascular remodeling and mitigate cardiac risk factors.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Issue number2
StatePublished - Apr 1 2017


  • PTH
  • hyperparathyroidism
  • hypoparathyroidism
  • parathyroid gland
  • parathyroid hormone

ASJC Scopus subject areas

  • Medicine(all)


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