TY - JOUR
T1 - The oxysterol-cxcr2 axis plays a key role in the recruitment of tumor-promoting neutrophils
AU - Raccosta, Laura
AU - Fontana, Raffaella
AU - Maggioni, Daniela
AU - Lanterna, Claudia
AU - Villablanca, Eduardo J.
AU - Paniccia, Aida
AU - Musumeci, Andrea
AU - Chiricozzi, Elena
AU - Trincavelli, Maria Letizia
AU - Daniele, Simona
AU - Martini, Claudia
AU - Gustafsson, Jan Ake
AU - Doglioni, Claudio
AU - Feo, Safiyè Gonzalvo
AU - Leiva, Andrea
AU - Ciampa, Maria Grazia
AU - Mauri, Laura
AU - Sensi, Cristina
AU - Prinetti, Alessandro
AU - Eberini, Ivano
AU - Mora, J. Rodrigo
AU - Claudio Bordignon, Bordignon
AU - Steffensen, Knut R.
AU - Sonnino, Sandro
AU - Sozzani, Silvano
AU - Traversari, Catia
AU - Russo, Vincenzo
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Tumor-infiltrating immune cells can be conditioned by molecules released within the microenvironment to thwart antitumor immune responses, thereby facilitating tumor growth. Among immune cells, neutrophils play an important protumorigenic role by favoring neoangiogenesis and/or by suppressing antitumor immune responses. Tumor-derived oxysterols have recently been shown to favor tumor growth by inhibiting dendritic cell migration toward lymphoid organs. We report that tumor-derived oxysterols recruit protumor neutrophils in a liver X receptor (LXR)-independent, CXCR2-dependent manner, thus favoring tumor growth by promoting neoangiogenesis and immunosuppression. We demonstrate that interfering with the oxysterol-CXCR2 axis delays tumor growth and prolongs the overall survival of tumor-bearing mice. These results identify an unanticipated protumor function of the oxysterol-CXCR2 axis and a possible target for cancer therapy
AB - Tumor-infiltrating immune cells can be conditioned by molecules released within the microenvironment to thwart antitumor immune responses, thereby facilitating tumor growth. Among immune cells, neutrophils play an important protumorigenic role by favoring neoangiogenesis and/or by suppressing antitumor immune responses. Tumor-derived oxysterols have recently been shown to favor tumor growth by inhibiting dendritic cell migration toward lymphoid organs. We report that tumor-derived oxysterols recruit protumor neutrophils in a liver X receptor (LXR)-independent, CXCR2-dependent manner, thus favoring tumor growth by promoting neoangiogenesis and immunosuppression. We demonstrate that interfering with the oxysterol-CXCR2 axis delays tumor growth and prolongs the overall survival of tumor-bearing mice. These results identify an unanticipated protumor function of the oxysterol-CXCR2 axis and a possible target for cancer therapy
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U2 - 10.1084/jem.20130440
DO - 10.1084/jem.20130440
M3 - Article
C2 - 23897983
AN - SCOPUS:84884230660
VL - 210
SP - 1711
EP - 1728
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 9
ER -