The orphan nuclear receptor RORα (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9

V. Giguère, B. Beatty, J. Squire, Neal G. Copeland, Nancy A. Jenkins

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

RORα is a novel member of the steroid/thyroid/retinoid receptor superfamily with unique DNA-binding properties. We have mapped the RORA gene by fluorescence in situ hybridization to human chromosome 15q21-q22. To map the mouse Rora gene, a partial mouse cDNA clone was isolated from brain. Using interspecific backcross analysis, we have mapped the Rora gene to mouse chromosome 9. This places the human RORA gene in the proximity of the PML gene, which is involved in a reciprocal chromosomal translocation t(15:17) with the RARA gene in patients with acute promyelocytic leukemia.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalGenomics
Volume28
Issue number3
DOIs
StatePublished - Aug 10 1995

ASJC Scopus subject areas

  • Genetics

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