The origins of glioma: E Pluribus Unum?

F. A. Siebzehnrubl, B. A. Reynolds, Angelo Vescovi, D. A. Steindler, L. P. Deleyrolle

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Malignant glioma is among of the most devastating, and least curable, types of cancer. Since the re-emergence of the cancer stem cell hypothesis, much progress has been made towards elucidating the cellular origin of these tumors. The hypothesis that tumors are hierarchically organized, with a cancer stem cell at the top that shares defining features with somatic stem cells and provides therapeutic refractoriness properties, has put adult stem cells into the limelight as prime suspect for malignant glioma. Much confusion still exists, though, as to the particular cell type and processes that lead to oncogenic transformation. In this review, we will discuss recent developments and novel hypotheses regarding the origin of malignant gliomas, especially glioblastoma. In particular, we argue that glioblastoma is the result of different pathways originating in multiple sources that all ultimately converge in the same disease. Further attention is devoted to potential scenarios leading to transformation of different stem/progenitor cell types of the brain, and the probability and relevance of these scenarios for malignant tumorigenesis.

Original languageEnglish (US)
Pages (from-to)1135-1147
Number of pages13
JournalGLIA
Volume59
Issue number8
DOIs
StatePublished - Aug 1 2011

Keywords

  • Brain tumor
  • Cancer stem cells
  • Glioblastoma
  • Tumor initiating cells

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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