The nucleolus and viral infection

Lei Wang, Xiao Ming Ren, Jun Ji Xing, Alan C. Zheng

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalVirologica Sinica
Volume25
Issue number3
DOIs
StatePublished - Jun 2010

Keywords

  • Cell cycle regulation
  • Nucleolus
  • Stress
  • Virus infection

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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