The normal and malignant mammary gland: A fresh look with ERβ onboard

M. Warner; S. Saji; J. Å Gustafsson

doi:10.1023/A:1009598828267

The normal and malignant mammary gland: A fresh look with ERβ onboard

M. Warner, S. Saji, J. Å Gustafsson

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)⁴ positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.

Original language	English (US)
Pages (from-to)	289-294
Number of pages	6
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	5
Issue number	3
DOIs	https://doi.org/10.1023/A:1009598828267
State	Published - 2000

Keywords

Estrogen receptor-β
Mammary gland

ASJC Scopus subject areas

Cancer Research

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10.1023/A:1009598828267

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title = "The normal and malignant mammary gland: A fresh look with ERβ onboard",

abstract = "Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.",

keywords = "Estrogen receptor-β, Mammary gland",

author = "M. Warner and S. Saji and Gustafsson, {J. {\AA}}",

note = "Funding Information: These projects are supported by grants from KaroBio AB, the Swedish Cancer Fund, and Scandinavia-Japan Sasakawa Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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T2 - A fresh look with ERβ onboard

AU - Warner, M.

AU - Saji, S.

AU - Gustafsson, J. Å

N1 - Funding Information: These projects are supported by grants from KaroBio AB, the Swedish Cancer Fund, and Scandinavia-Japan Sasakawa Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2000

Y1 - 2000

N2 - Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.

AB - Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.

KW - Estrogen receptor-β

KW - Mammary gland

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The normal and malignant mammary gland: A fresh look with ERβ onboard

Abstract

Keywords

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