The normal and malignant mammary gland: A fresh look with ERβ onboard

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalJournal of Mammary Gland Biology and Neoplasia
Volume5
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Estrogen receptor-β
  • Mammary gland

ASJC Scopus subject areas

  • Cancer Research

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