The no-observed-adverse-effect level (NOAEL) of baby aloe powder (BAP) for nutraceutical application based upon toxicological evaluation

Seung Jun Kwack, Seon Gil Do, Young Woo Kim, Yeon Joo Kim, Hyo Min Gwak, Hyun Jong Park, Taehyun Roh, Min Kyung Shin, Seong Kwang Lim, Hyung Sik Kim, Byung Mu Lee

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1 Scopus citations

Abstract

Aloe has been used in versatile herbal medications and nutraceuticals throughout history. Aloe is widely considered to be generally safe for humans and used globally. The effectiveness and pharmacological properties of aloe are dependent upon when the plant is collected. However, little is known about the toxicology of whole-body aloe collected within less than 1 yr. Based upon widespread exposure to aloe, it is important to determine a daily intake level of this chemical to ensure its safety for humans. To determine the no-observed-adverse-effect level (NOAEL) of baby aloe powder (BAP) for clinical application, Sprague-Dawley (SD) rats were treated orally for 4 wk with 4 different concentrations: 0, 0.125, 0.5, and 2 g/kg body weight (bw). In this study, no significant or dose-dependent toxicological effects of BAP were observed in biochemical or hematological parameters, urinalysis, clinical signs, body weight, and food and water consumption. There were changes in some biomarkers in certain treated groups compared to controls; however, all values were within their reference ranges and not dose-dependent. Based on these results, the NOAEL of BAP was estimated to be greater than 2 g/kg bw in male and 2 g/kg bw in female SD rats. Collectively, these data suggest that BAP used in this study did not produce any marked subacute toxic effects up to a maximum concentration of 2 g/kg bw, and thus use in nutraceuticals and in pharmaceutical and cosmetic applications at a concentration of >2 g/kg is warranted.

Original languageEnglish (US)
Pages (from-to)1319-1331
Number of pages13
JournalJournal of Toxicology and Environmental Health - Part A
Volume77
DOIs
StatePublished - Dec 27 2014

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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