TY - JOUR
T1 - The neurophysiological representation of imagined somatosensory percepts in human cortex
AU - Bashford, Luke
AU - Rosenthal, Isabelle
AU - Kellis, Spencer
AU - Pejsa, Kelsie
AU - Kramer, Daniel
AU - Lee, Brian
AU - Liu, Charles
AU - Andersen, Richard A.
N1 - Publisher Copyright:
© 2021 Society for Neuroscience. All rights reserved.
PY - 2021/3/10
Y1 - 2021/3/10
N2 - Intracortical microstimulation (ICMS) in human primary somatosensory cortex (S1) has been used to successfully evoke naturalistic sensations. However, the neurophysiological mechanisms underlying the evoked sensations remain unknown. To understand how specific stimulation parameters elicit certain sensations we must first understand the representation of those sensations in the brain. In this study we record from intracortical microelectrode arrays implanted in S1, premotor cortex, and posterior parietal cortex of a male human participant performing a somatosensory imagery task. The sensations imagined were those previously elicited by ICMS of S1, in the same array of the same participant. In both spike and local field potential recordings, features of the neural signal can be used to classify different imagined sensations. These features are shown to be stable over time. The sensorimotor cortices only encode the imagined sensation during the imagery task, while posterior parietal cortex encodes the sensations starting with cue presentation. These findings demonstrate that different aspects of the sensory experience can be individually decoded from intracortically recorded human neural signals across the cortical sensory network. Activity underlying these unique sensory representations may inform the stimulation parameters for precisely eliciting specific sensations via ICMS in future work.
AB - Intracortical microstimulation (ICMS) in human primary somatosensory cortex (S1) has been used to successfully evoke naturalistic sensations. However, the neurophysiological mechanisms underlying the evoked sensations remain unknown. To understand how specific stimulation parameters elicit certain sensations we must first understand the representation of those sensations in the brain. In this study we record from intracortical microelectrode arrays implanted in S1, premotor cortex, and posterior parietal cortex of a male human participant performing a somatosensory imagery task. The sensations imagined were those previously elicited by ICMS of S1, in the same array of the same participant. In both spike and local field potential recordings, features of the neural signal can be used to classify different imagined sensations. These features are shown to be stable over time. The sensorimotor cortices only encode the imagined sensation during the imagery task, while posterior parietal cortex encodes the sensations starting with cue presentation. These findings demonstrate that different aspects of the sensory experience can be individually decoded from intracortically recorded human neural signals across the cortical sensory network. Activity underlying these unique sensory representations may inform the stimulation parameters for precisely eliciting specific sensations via ICMS in future work.
KW - Brain-machine interface
KW - Human
KW - Intracortical microstimulation
KW - Sensation
KW - Somatosensation
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UR - http://www.scopus.com/inward/citedby.url?scp=85102909477&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.2460-20.2021
DO - 10.1523/JNEUROSCI.2460-20.2021
M3 - Article
C2 - 33483431
AN - SCOPUS:85102909477
SN - 0270-6474
VL - 41
SP - 2180
EP - 2185
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 10
ER -