Abstract
The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.
Original language | English (US) |
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Pages (from-to) | 17-24 |
Number of pages | 8 |
Journal | Colloids and Surfaces B: Biointerfaces |
Volume | 124 |
DOIs | |
State | Published - Dec 1 2014 |
Keywords
- Nano-bio interface
- Nanoparticles
- Plasma
- Protein corona
- Proteins
ASJC Scopus subject areas
- Biotechnology
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry