TY - JOUR
T1 - The nano-plasma interface
T2 - Implications of the protein corona
AU - Wolfram, Joy
AU - Yang, Yong
AU - Shen, Jianliang
AU - Moten, Asad
AU - Chen, Chunying
AU - Shen, Haifa
AU - Ferrari, Mauro
AU - Zhao, Yuliang
N1 - Funding Information:
The work was supported by funds from the NSFC ( 21320102003 and 21277037 ) (Y.Z.), MOST 973 Program (2012CB934001 and 2012CB932601) (Y.Z.) and the Houston Methodist Research Institute (M.F.). Partial funds were acquired from the Ernest Cockrell Jr. Distinguished Endowed Chair (M.F.), the U.S. Department of Defense ( W81XWH-09-1-0212 ) (M.F.), the National Institute of Health (U54CA143837, U54CA151668) (M.F.), Nylands Nation Finland (J.W.), Viktoriastiftelsen Finland (J.W.), Department of Defense grant W81XWH-12-1-0414 (M.F.) and the State of Texas CPRIT grant RP121071 (M.F. and H.S.)
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.
AB - The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.
KW - Nano-bio interface
KW - Nanoparticles
KW - Plasma
KW - Protein corona
KW - Proteins
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U2 - 10.1016/j.colsurfb.2014.02.035
DO - 10.1016/j.colsurfb.2014.02.035
M3 - Article
C2 - 24656615
AN - SCOPUS:84909582630
VL - 124
SP - 17
EP - 24
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
SN - 0927-7765
ER -