The nano-plasma interface: Implications of the protein corona

Joy Wolfram; Yong Yang; Jianliang Shen; Asad Moten; Chunying Chen; Haifa Shen; Mauro Ferrari; Yuliang Zhao

doi:10.1016/j.colsurfb.2014.02.035

The nano-plasma interface: Implications of the protein corona

Joy Wolfram, Yong Yang, Jianliang Shen, Asad Moten, Chunying Chen, Haifa Shen, Mauro Ferrari, Yuliang Zhao

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.

Original language	English (US)
Pages (from-to)	17-24
Number of pages	8
Journal	Colloids and Surfaces B: Biointerfaces
Volume	124
DOIs	https://doi.org/10.1016/j.colsurfb.2014.02.035
State	Published - Dec 1 2014

Keywords

Nano-bio interface
Nanoparticles
Plasma
Protein corona
Proteins

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/j.colsurfb.2014.02.035

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abstract = "The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.",

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AU - Moten, Asad

AU - Chen, Chunying

AU - Shen, Haifa

AU - Ferrari, Mauro

AU - Zhao, Yuliang

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AB - The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.

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The nano-plasma interface: Implications of the protein corona

Abstract

Keywords

ASJC Scopus subject areas

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