TY - JOUR
T1 - The nano-plasma interface
T2 - Implications of the protein corona
AU - Wolfram, Joy
AU - Yang, Yong
AU - Shen, Jianliang
AU - Moten, Asad
AU - Chen, Chunying
AU - Shen, Haifa
AU - Ferrari, Mauro
AU - Zhao, Yuliang
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.
AB - The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.
KW - Nano-bio interface
KW - Nanoparticles
KW - Plasma
KW - Protein corona
KW - Proteins
UR - http://www.scopus.com/inward/record.url?scp=84909582630&partnerID=8YFLogxK
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U2 - 10.1016/j.colsurfb.2014.02.035
DO - 10.1016/j.colsurfb.2014.02.035
M3 - Article
C2 - 24656615
AN - SCOPUS:84909582630
SN - 0927-7765
VL - 124
SP - 17
EP - 24
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -