The nano-plasma interface: Implications of the protein corona

Joy Wolfram, Yong Yang, Jianliang Shen, Asad Moten, Chunying Chen, Haifa Shen, Mauro Ferrari, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

147 Scopus citations


The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
StatePublished - Dec 1 2014


  • Nano-bio interface
  • Nanoparticles
  • Plasma
  • Protein corona
  • Proteins

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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