The murine Il-6 gene maps to the proximal region of chromosome 5

B. A. Mock; R. P. Nordan; M. J. Justice; C. Kozak; N. A. Jenkins; N. G. Copeland; S. C. Clark; G. G. Wong; S. Rudikoff

The murine Il-6 gene maps to the proximal region of chromosome 5

B. A. Mock, R. P. Nordan, M. J. Justice, C. Kozak, N. A. Jenkins, N. G. Copeland, S. C. Clark, G. G. Wong, S. Rudikoff

Research output: Contribution to journal › Article › peer-review

Abstract

Murine Il-6 cDNAs were isolated by cross-hybrization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.

Original language	English (US)
Pages (from-to)	1372-1376
Number of pages	5
Journal	Journal of Immunology
Volume	142
Issue number	4
State	Published - 1989

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "The murine Il-6 gene maps to the proximal region of chromosome 5",

abstract = "Murine Il-6 cDNAs were isolated by cross-hybrization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.",

author = "Mock, \{B. A.\} and Nordan, \{R. P.\} and Justice, \{M. J.\} and C. Kozak and Jenkins, \{N. A.\} and Copeland, \{N. G.\} and Clark, \{S. C.\} and Wong, \{G. G.\} and S. Rudikoff",

year = "1989",

language = "English (US)",

volume = "142",

pages = "1372--1376",

journal = "Journal of Immunology",

issn = "0022-1767",

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T1 - The murine Il-6 gene maps to the proximal region of chromosome 5

AU - Mock, B. A.

AU - Nordan, R. P.

AU - Justice, M. J.

AU - Kozak, C.

AU - Jenkins, N. A.

AU - Copeland, N. G.

AU - Clark, S. C.

AU - Wong, G. G.

AU - Rudikoff, S.

PY - 1989

Y1 - 1989

N2 - Murine Il-6 cDNAs were isolated by cross-hybrization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.

AB - Murine Il-6 cDNAs were isolated by cross-hybrization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.

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C2 - 2563387

AN - SCOPUS:0024562530

SN - 0022-1767

VL - 142

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EP - 1376

JO - Journal of Immunology

JF - Journal of Immunology

IS - 4

ER -

The murine Il-6 gene maps to the proximal region of chromosome 5

Abstract

ASJC Scopus subject areas

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