The murine Il-6 gene maps to the proximal region of chromosome 5

B. A. Mock, R. P. Nordan, M. J. Justice, C. Kozak, Nancy A. Jenkins, Neal G. Copeland, S. C. Clark, G. G. Wong, S. Rudikoff

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Murine Il-6 cDNAs were isolated by cross-hybrization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.

Original languageEnglish (US)
Pages (from-to)1372-1376
Number of pages5
JournalJournal of Immunology
Volume142
Issue number4
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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