The Murine Homologue of the Human Interleukin-8 Receptor Type B Maps near the Ity-Lsh-Bcg Disease Resistance Locus

Douglas Pat Cerretti; Nicole Nelson; Carl J. Kozlosky; Philip J. Morrissey; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Jennifer K. Dosik; Beverly A. Mock

doi:10.1006/geno.1993.1486

The Murine Homologue of the Human Interleukin-8 Receptor Type B Maps near the Ity-Lsh-Bcg Disease Resistance Locus

Douglas Pat Cerretti, Nicole Nelson, Carl J. Kozlosky, Philip J. Morrissey, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Jennifer K. Dosik, Beverly A. Mock

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Interleukin-8 (IL-8), a member of the chemokine α subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL- 8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM ± 1 standard error) from the centromere: Mylf-7.9 ± 2.7-Lsh-Ity-Bcg-1.9 ± 1.4- Il8rb-1.9 ± 1.4-Vil-5.9 ± 2.3-Acrg-2.9 ± 1.7-Bcl-2.

Original language	English (US)
Pages (from-to)	410-413
Number of pages	4
Journal	Genomics
Volume	18
Issue number	2
DOIs	https://doi.org/10.1006/geno.1993.1486
State	Published - Nov 1993

ASJC Scopus subject areas

Genetics

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@article{16f2b12d07b143beaf245f34e861149e,

title = "The Murine Homologue of the Human Interleukin-8 Receptor Type B Maps near the Ity-Lsh-Bcg Disease Resistance Locus",

abstract = "Interleukin-8 (IL-8), a member of the chemokine α subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL- 8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71\% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM ± 1 standard error) from the centromere: Mylf-7.9 ± 2.7-Lsh-Ity-Bcg-1.9 ± 1.4- Il8rb-1.9 ± 1.4-Vil-5.9 ± 2.3-Acrg-2.9 ± 1.7-Bcl-2.",

author = "Cerretti, \{Douglas Pat\} and Nicole Nelson and Kozlosky, \{Carl J.\} and Morrissey, \{Philip J.\} and Copeland, \{Neal G.\} and Gilbert, \{Debra J.\} and Jenkins, \{Nancy A.\} and Dosik, \{Jennifer K.\} and Mock, \{Beverly A.\}",

year = "1993",

month = nov,

doi = "10.1006/geno.1993.1486",

language = "English (US)",

volume = "18",

pages = "410--413",

journal = "Genomics",

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AU - Cerretti, Douglas Pat

AU - Nelson, Nicole

AU - Kozlosky, Carl J.

AU - Morrissey, Philip J.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Dosik, Jennifer K.

AU - Mock, Beverly A.

PY - 1993/11

Y1 - 1993/11

N2 - Interleukin-8 (IL-8), a member of the chemokine α subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL- 8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM ± 1 standard error) from the centromere: Mylf-7.9 ± 2.7-Lsh-Ity-Bcg-1.9 ± 1.4- Il8rb-1.9 ± 1.4-Vil-5.9 ± 2.3-Acrg-2.9 ± 1.7-Bcl-2.

AB - Interleukin-8 (IL-8), a member of the chemokine α subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL- 8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM ± 1 standard error) from the centromere: Mylf-7.9 ± 2.7-Lsh-Ity-Bcg-1.9 ± 1.4- Il8rb-1.9 ± 1.4-Vil-5.9 ± 2.3-Acrg-2.9 ± 1.7-Bcl-2.

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The Murine Homologue of the Human Interleukin-8 Receptor Type B Maps near the Ity-Lsh-Bcg Disease Resistance Locus

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