Interleukin-8 (IL-8), a member of the chemokine α subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL- 8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM ± 1 standard error) from the centromere: Mylf-7.9 ± 2.7-Lsh-Ity-Bcg-1.9 ± 1.4- Il8rb-1.9 ± 1.4-Vil-5.9 ± 2.3-Acrg-2.9 ± 1.7-Bcl-2.
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