The Murine Homologue of the Human Interleukin-8 Receptor Type B Maps near the Ity-Lsh-Bcg Disease Resistance Locus

Douglas Pat Cerretti, Nicole Nelson, Carl J. Kozlosky, Philip J. Morrissey, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Jennifer K. Dosik, Beverly A. Mock

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Interleukin-8 (IL-8), a member of the chemokine α subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL- 8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM ± 1 standard error) from the centromere: Mylf-7.9 ± 2.7-Lsh-Ity-Bcg-1.9 ± 1.4- Il8rb-1.9 ± 1.4-Vil-5.9 ± 2.3-Acrg-2.9 ± 1.7-Bcl-2.

Original languageEnglish (US)
Pages (from-to)410-413
Number of pages4
JournalGenomics
Volume18
Issue number2
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Genetics

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