Abstract

We encourage studies on the effectiveness of multiple sclerosis drugs for the treatment of ARDS in COVID-19 infection. These drugs, through the inhibition of the RhoA/actin-dependent expression of virus receptors in the macrophages and macrophage recruitment to the lungs, have the potential to inhibit cytokine storm of lung macrophages, reduce or eliminate ARDS and improve the outcome of COVID-19 infection.

Original languageEnglish (US)
Article number102437
JournalMultiple Sclerosis and Related Disorders
Volume45
DOIs
StatePublished - Oct 2020

Keywords

  • Azetidines/therapeutic use
  • Benzyl Compounds/therapeutic use
  • Betacoronavirus/drug effects
  • Coronavirus Infections/complications
  • Enzyme Inhibitors/therapeutic use
  • Fingolimod Hydrochloride/therapeutic use
  • Humans
  • Multiple Sclerosis/drug therapy
  • Pandemics
  • Pneumonia, Viral/complications
  • Respiratory Distress Syndrome, Adult/drug therapy
  • rhoA GTP-Binding Protein/antagonists & inhibitors

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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