The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease

Thomas Wong; Reece Kang; Kyuson Yun

doi:10.3389/fimmu.2025.1525567

The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease

Thomas Wong, Reece Kang, Kyuson Yun

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

S100A4 is a Ca²⁺-binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances in the understanding of S100A4 function in immune cells, comparing and contrasting S100A4 regulation of immune responses in cancer and chronic inflammatory diseases. We provide evidence that S100A4 regulation of immune cell function has a profound role in promoting the pathogenesis of cancer and pro-inflammatory conditions. Finally, we discuss relevant future directions to target S100A4 therapeutically in different disease states.

Original language	English (US)
Article number	1525567
Journal	Frontiers in immunology
Volume	16
DOIs	https://doi.org/10.3389/fimmu.2025.1525567
State	Published - 2025

Keywords

cancer
chronic inflammation
fibrosis
FSP-1
immune suppression
macrophages
S100A4
T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2025.1525567

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title = "The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease",

abstract = "S100A4 is a Ca2+-binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances in the understanding of S100A4 function in immune cells, comparing and contrasting S100A4 regulation of immune responses in cancer and chronic inflammatory diseases. We provide evidence that S100A4 regulation of immune cell function has a profound role in promoting the pathogenesis of cancer and pro-inflammatory conditions. Finally, we discuss relevant future directions to target S100A4 therapeutically in different disease states.",

keywords = "cancer, chronic inflammation, fibrosis, FSP-1, immune suppression, macrophages, S100A4, T cells",

author = "Thomas Wong and Reece Kang and Kyuson Yun",

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year = "2025",

doi = "10.3389/fimmu.2025.1525567",

language = "English (US)",

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T1 - The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease

AU - Wong, Thomas

AU - Kang, Reece

AU - Yun, Kyuson

PY - 2025

Y1 - 2025

N2 - S100A4 is a Ca2+-binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances in the understanding of S100A4 function in immune cells, comparing and contrasting S100A4 regulation of immune responses in cancer and chronic inflammatory diseases. We provide evidence that S100A4 regulation of immune cell function has a profound role in promoting the pathogenesis of cancer and pro-inflammatory conditions. Finally, we discuss relevant future directions to target S100A4 therapeutically in different disease states.

AB - S100A4 is a Ca2+-binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances in the understanding of S100A4 function in immune cells, comparing and contrasting S100A4 regulation of immune responses in cancer and chronic inflammatory diseases. We provide evidence that S100A4 regulation of immune cell function has a profound role in promoting the pathogenesis of cancer and pro-inflammatory conditions. Finally, we discuss relevant future directions to target S100A4 therapeutically in different disease states.

KW - cancer

KW - chronic inflammation

KW - fibrosis

KW - FSP-1

KW - immune suppression

KW - macrophages

KW - S100A4

KW - T cells

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DO - 10.3389/fimmu.2025.1525567

M3 - Review article

C2 - 40078995

AN - SCOPUS:86000643872

SN - 1664-3224

VL - 16

JO - Frontiers in immunology

JF - Frontiers in immunology

M1 - 1525567

ER -

The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease

Abstract

Keywords

ASJC Scopus subject areas

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