The mouseaquaporin-1gene

Chulso Moon; John B. Williams; Gregory M. Preston; Neal G. Copeland; Debra J. Gilbert; Daniel Nathans; Nancy A. Jenkins; Peter Agre

doi:10.1006/geno.1995.0029

The mouseaquaporin-1gene

Chulso Moon, John B. Williams, Gregory M. Preston, Neal G. Copeland, Debra J. Gilbert, Daniel Nathans, Nancy A. Jenkins, Peter Agre

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouse Aqp1, the structural gene was isolated and a restriction map was constructed. The 13-kb Aqp1 gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 hp 5' to the translation initiation site and 20 bp 3' from a TATAA consensus sequence. Aqp1 was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, where AQP1 had previously been localized. These studies have revealed marked structural similarities between the mouse Aqp1 and the human AQP1 genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.

Original language	English (US)
Pages (from-to)	354-357
Number of pages	4
Journal	Genomics
Volume	30
Issue number	2
DOIs	https://doi.org/10.1006/geno.1995.0029
State	Published - Nov 1995

ASJC Scopus subject areas

Genetics

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title = "The mouseaquaporin-1gene",

abstract = "Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouse Aqp1, the structural gene was isolated and a restriction map was constructed. The 13-kb Aqp1 gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 hp 5' to the translation initiation site and 20 bp 3' from a TATAA consensus sequence. Aqp1 was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, where AQP1 had previously been localized. These studies have revealed marked structural similarities between the mouse Aqp1 and the human AQP1 genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.",

author = "Chulso Moon and Williams, {John B.} and Preston, {Gregory M.} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Daniel Nathans and Jenkins, {Nancy A.} and Peter Agre",

note = "Funding Information: We thank David Valle, Brian Cho, and Anthony Lanahan for suggestions, assistance, and resources. This work was supported in part by National Heart, Lung and Blood Institute Grants HL33991 and HL48268 and by the National Cancer Institute, under Contract NO1-CO-46000 with ABL.",

year = "1995",

month = nov,

doi = "10.1006/geno.1995.0029",

language = "English (US)",

volume = "30",

pages = "354--357",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

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T1 - The mouseaquaporin-1gene

AU - Moon, Chulso

AU - Williams, John B.

AU - Preston, Gregory M.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Nathans, Daniel

AU - Jenkins, Nancy A.

AU - Agre, Peter

N1 - Funding Information: We thank David Valle, Brian Cho, and Anthony Lanahan for suggestions, assistance, and resources. This work was supported in part by National Heart, Lung and Blood Institute Grants HL33991 and HL48268 and by the National Cancer Institute, under Contract NO1-CO-46000 with ABL.

PY - 1995/11

Y1 - 1995/11

N2 - Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouse Aqp1, the structural gene was isolated and a restriction map was constructed. The 13-kb Aqp1 gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 hp 5' to the translation initiation site and 20 bp 3' from a TATAA consensus sequence. Aqp1 was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, where AQP1 had previously been localized. These studies have revealed marked structural similarities between the mouse Aqp1 and the human AQP1 genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.

AB - Members of the aquaporin family of molecular water transporters are expressed in diverse epithelia and in complex developmental patterns. Using a cDNA for mouse Aqp1, the structural gene was isolated and a restriction map was constructed. The 13-kb Aqp1 gene contains four exons with intronic boundaries corresponding to other known aquaporin genes. Transcription begins 67 hp 5' to the translation initiation site and 20 bp 3' from a TATAA consensus sequence. Aqp1 was localized by interspecific mouse backcross mapping to the central region of mouse chromosome 6 syntenic with human chromosome 7p14, where AQP1 had previously been localized. These studies have revealed marked structural similarities between the mouse Aqp1 and the human AQP1 genes, suggesting that further comparative studies may provide molecular insight into genetic regulatory features shared by both species.

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The mouseaquaporin-1gene

Abstract

ASJC Scopus subject areas

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