The mouse CD69 gene: Structure, expression, and mapping to the NK gene complex

Steven F. Ziegler, Steven D. Levin, Lisabeth Johnson, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Elizabeth Baker, Grant R. Sutherland, Andrew L. Feldhaus, Fred Ramsdell

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

CD69 is a rapidly induced T cell activation Ag that is also expressed in an inducible fashion on cells of most, if not all, hematopoietic lineages. Molecular cloning has shown that CD69 is a type II membrane glycoprotein that is a member of the C-type lectin family. In this report we have shown that induction of CD69 mRNA in activated murine thymocytes and T cells is very rapid, peaking between 30 and 60 min poststimulation, and transient, dropping to nearly resting levels by 8 h. An analysis of the mouse CD69 gene structure showed the gene to consist of 5 exons and have a phorbol ester-inducible promoter element within the first 700 bp upstream of the start of transcription. Chromosomal mapping placed the mouse CD69 gene on the long arm of chromosome 6 near the NK gene complex that contains the related NKR-P1 and Ly-49 gene families. The human CD69 gene mapped to chromosome 12p13 near the related NKG2 gene cluster and in a region associated with rearrangements in approximately 10% of cases of childhood acute lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)1228-1236
Number of pages9
JournalJournal of Immunology
Volume152
Issue number3
StatePublished - Feb 1 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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