The mouse and human excitatory amino acid transporter gene (eaat1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5

M. A. Kirschner, J. L. Arriza, Neal G. Copeland, D. J. Gilbert, Nancy A. Jenkins, E. Magenis, S. G. Amara

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The gene for human excitatory amino acid transporter (EAAT1) was localized to the distal region of human chromosome 5p13 by in situ hybridization of metaphase chromosome spreads. Interspecific backcross analysis identified the mouse Eaat1 locus in a region of 5p13 homology on mouse chromosome 15. Markers that are linked with EAAT1 on both human and mouse chromosomes include the receptors for leukemia inhibitory factor, interleukin-7, and prolactin. The Eaat1 locus appears not to be linked to the epilepsy mutant stg locus, which is also on chromosome 15. The EAAT1 locus is located in a region of 5p deletions that have been associated with mental retardation and microcephaly.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalGenomics
Volume22
Issue number3
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Genetics

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