The Mos proto-oncogene maps near the centromere on mouse chromosome 4

Friedrich Propst, George F. Vande Woude, Nancy A. Jenkins, Neal G. Copeland, Barbara K. Lee, Patricia A. Hunt, Eva M. Eicher

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The Mos proto-oncogene, the cellular homolog of the transforming gene of Moloney murine sarcoma virus, was originally assigned to mouse chromosome 4 using independent panels of mouse/hamster somatic cell hybrids. By in situ hybridization to metaphase chromosomes and standard genetic backcrosses, we have confirmed this assignment and determined that Mos maps near the centromere in a region devoid of other markers. We have also identified a restriction fragment length polymorphism (RFLP) that defines two alleles of the Mos locus in selected inbred strains of laboratory mice. Using the RFLP, we determined the strain distribution pattern for the Mos gene in three sets of recombinant inbred strains and in five strains congenic for histocompatibility antigen genes localized on chromosome 4. These results establish Mos as a useful marker in a poorly characterized region of the mouse genome. In addition, these results will facilitate the genetic analysis of the Mos locus.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalGenomics
Volume5
Issue number1
DOIs
StatePublished - Jul 1989

ASJC Scopus subject areas

  • Genetics

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