The molecular basis of cardiac arrhythmias in patients with cardiomyopathy.

Sen Ji, David Cesario, Miguel Valderrabano, Kalyanam Shivkumar

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Cardiac arrhythmias are a leading cause of mortality and morbidity in Western society. In some specific instances, these arrhythmias are caused by abnormalities of cardiac ion channels, such as sodium, calcium, and potassium channels, which carry ionic currents and are fundamental determinants of cardiac excitability. Abnormalities of these ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function of channels, which can predispose to arrhythmias. During heart failure, many channels also malfunction because of altered expression, resulting in lethal arrhythmias.

Original languageEnglish (US)
Pages (from-to)98-103
Number of pages6
JournalCurrent heart failure reports
Issue number3
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Emergency Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'The molecular basis of cardiac arrhythmias in patients with cardiomyopathy.'. Together they form a unique fingerprint.

Cite this