TY - JOUR
T1 - The molecular basis of cardiac arrhythmias in patients with cardiomyopathy.
AU - Ji, Sen
AU - Cesario, David
AU - Valderrabano, Miguel
AU - Shivkumar, Kalyanam
PY - 2004/9
Y1 - 2004/9
N2 - Cardiac arrhythmias are a leading cause of mortality and morbidity in Western society. In some specific instances, these arrhythmias are caused by abnormalities of cardiac ion channels, such as sodium, calcium, and potassium channels, which carry ionic currents and are fundamental determinants of cardiac excitability. Abnormalities of these ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function of channels, which can predispose to arrhythmias. During heart failure, many channels also malfunction because of altered expression, resulting in lethal arrhythmias.
AB - Cardiac arrhythmias are a leading cause of mortality and morbidity in Western society. In some specific instances, these arrhythmias are caused by abnormalities of cardiac ion channels, such as sodium, calcium, and potassium channels, which carry ionic currents and are fundamental determinants of cardiac excitability. Abnormalities of these ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function of channels, which can predispose to arrhythmias. During heart failure, many channels also malfunction because of altered expression, resulting in lethal arrhythmias.
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U2 - 10.1007/s11897-004-0018-3
DO - 10.1007/s11897-004-0018-3
M3 - Review article
C2 - 16036032
AN - SCOPUS:23944438481
VL - 1
SP - 98
EP - 103
JO - Curr Heart Fail Rep
JF - Curr Heart Fail Rep
SN - 1546-9530
IS - 3
ER -