TY - JOUR
T1 - The mitotic index in psoriatic plaques and their response to PUVA therapy
AU - Goldberg, Leonard Harry
AU - COX, A. J.
AU - ABEL, E. A.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The mitotic index of pretreatment plaques of chronic psoriasis was determined before treatment with PUVA. There was a wide variation in mitotic indices in different patients. Treatment was given with UV-A 2 h after oral ingestion of 8-methoxypsoralen (8-MOP) two or three times per week, with increasing doses of UV-A. Patients were considered cleared if there was 95% clearing of all psoriatic plaques. There was no correlation the mitotic index and the response to treatment, as measured by either the number of joules administered or the number of treatments until the lesions cleared. This suggests that the action of PUVA in psoriasis is not dependent on the amount of increase in epidermal proliferation.
AB - The mitotic index of pretreatment plaques of chronic psoriasis was determined before treatment with PUVA. There was a wide variation in mitotic indices in different patients. Treatment was given with UV-A 2 h after oral ingestion of 8-methoxypsoralen (8-MOP) two or three times per week, with increasing doses of UV-A. Patients were considered cleared if there was 95% clearing of all psoriatic plaques. There was no correlation the mitotic index and the response to treatment, as measured by either the number of joules administered or the number of treatments until the lesions cleared. This suggests that the action of PUVA in psoriasis is not dependent on the amount of increase in epidermal proliferation.
UR - http://www.scopus.com/inward/record.url?scp=0018874771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018874771&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.1980.tb06552.x
DO - 10.1111/j.1365-2133.1980.tb06552.x
M3 - Article
C2 - 7387882
AN - SCOPUS:0018874771
VL - 102
SP - 401
EP - 405
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 4
ER -