The microbiota link to irritable bowel syndrome an emerging story

Ian B. Jeffery, Eamonn M.M. Quigley, Lena Öhman, Magnus Simrén, Paul W. O'Toole

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Irritable bowel syndrome (IBS) is a clinically heterogeneous disorder which is likely to involve a number of causative factors. The contribution of altered intestinal microbiota composition or function to this disorder is controversial, and is the subject of much current research. Until recently, the technical limitations of the methodologies available have not permitted an adequate survey of low-abundance microbial species. Recent technological developments have enabled the analysis of the global population of the microbiome using high through-put, culture independent, 16S rRNA amplicon pyrosequencing. Using these new methodologies, we are able to gain important biological insights into the link between functional bowel disorders and the microbiome. This addendum contextualizes and summarizes the results of these studies, and defines the future challenges and opportunities in the field.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalGut Microbes
Volume3
Issue number6
DOIs
StatePublished - Nov 2012

Keywords

  • Allergy
  • Gastroenteritis
  • Irritable bowel syndrome (IBS)
  • Microbiome
  • Microbiota

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

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