TY - JOUR
T1 - The merits of vascular targeting for gynecologic malignancies
AU - Kamat, Aparna A.
AU - Sood, Anil K.
N1 - Funding Information:
This work is supported through the University of Texas M.D. Anderson Cancer Center SPORE in ovarian cancer (1P50CA83639), Department of the Army (W81 XWH-04-0227), and the National Cancer Institute (CA 11079301 and CA 10929801).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/11
Y1 - 2005/11
N2 - Neovascularization is an early and critical step in tumor development and progression. Tumor vessels are distinct from their normal counterparts morphologically as well as at a molecular level. Recent studies on factors involved in tumor vascular development have identified new therapeutic targets for inhibiting tumor neovascularization and thus tumor progression. However, the process of tumor blood vessel formation is complex, and each tumor exhibits unique features in its vasculature. An understanding of the relative contribution of various pathways in the development of tumor vasculature is critical for developing effective and selective therapeutic approaches. Several such agents are currently in clinical trials, and many others are under development. In this review, the mechanisms and factors involved in tumor blood vessel formation are discussed. In addition, selected novel classes of antivascular therapies, including those targeting tumor endothelial cells and other components of the tumor vasculature, are summarized.
AB - Neovascularization is an early and critical step in tumor development and progression. Tumor vessels are distinct from their normal counterparts morphologically as well as at a molecular level. Recent studies on factors involved in tumor vascular development have identified new therapeutic targets for inhibiting tumor neovascularization and thus tumor progression. However, the process of tumor blood vessel formation is complex, and each tumor exhibits unique features in its vasculature. An understanding of the relative contribution of various pathways in the development of tumor vasculature is critical for developing effective and selective therapeutic approaches. Several such agents are currently in clinical trials, and many others are under development. In this review, the mechanisms and factors involved in tumor blood vessel formation are discussed. In addition, selected novel classes of antivascular therapies, including those targeting tumor endothelial cells and other components of the tumor vasculature, are summarized.
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U2 - 10.1007/s11912-005-0009-x
DO - 10.1007/s11912-005-0009-x
M3 - Review article
C2 - 16221381
AN - SCOPUS:28044441144
VL - 7
SP - 444
EP - 450
JO - Current Oncology Reports
JF - Current Oncology Reports
SN - 1523-3790
IS - 6
ER -