The medullary cerebrovascular vasodilator area mediates cerebrovascular vasodilation and electroencephalogram synchronization elicited from cerebellar fastigial nucleus in Sprague-Dawley rats

Eugene V. Golanov, John R.C. Christensen, Donald J. Reis

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We investigated whether the medullary cerebrovasodilator area (MCVA), a region of ventral medulla mediating elevations of regional cerebral blood flow (rCBF) and electroencephalogram (EEG) synchronization elicited in cerebral cortex from stimulation of reticulospinal neurons of rostral ventrolateral medulla (RVLM), also mediates comparable responses from the cerebellar fastigial nucleus (FN). In spinalized rats, electrical stimulation of MCVA, RVLM or FN elevated rCBF and synchronized the EEG. The FN-evoked responses were significantly attenuated or blocked by bilateral lesions of MCVA. The MCVA is a novel region of medullary reticular formation mediating actions of medullary and cerebellar centers on rCBF and EEG to link visceral centers of brainstem and cerebral cortex. Copyright (C) 2000.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalNeuroscience Letters
Volume288
Issue number3
DOIs
StatePublished - Jul 21 2000

Keywords

  • Cerebellum
  • Cerebral blood flow
  • Fastigial nucleus
  • Medulla oblongata
  • Medullary cerebrovasodilator area
  • Rostral ventrolateral medulla

ASJC Scopus subject areas

  • Neuroscience(all)

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