The many faces of histone H3K79 methylation

Zeenat Farooq, Shahid Banday, Tej K. Pandita, Mohammad Altaf

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 located within the globular domain of histone H3. Dot1 was initially identified by a genetic screen as a disruptor of telomeric silencing in Saccharomyces cerevisiae; further, it is the only known non-SET domain containing histone methyltransferase. Methylation of H3K79 is involved in the regulation of telomeric silencing, cellular development, cell-cycle checkpoint, DNA repair, and regulation of transcription. hDot1L-mediated H3K79 methylation appears to have a crucial role in transformation as well as disease progression in leukemias involving several oncogenic fusion proteins. This review summarizes the multiple functions of Dot1/hDOT1L in a range of cellular processes.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalMutation Research - Reviews in Mutation Research
StatePublished - Apr 1 2016


  • Chromatin
  • DNA repair
  • Histone methylation

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis


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