The Macrophages and Intestinal Symbiosis

Malgorzata Kloc, Ahmed Uosef, Mahmoud Elshawwaf, Ahmed Adel Abbas Abdelshafy, Kamal Mamdoh Kamal Elsaid, Jacek Z. Kubiak, Rafik Mark Ghobrial

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The human intestinal tract is inhabited by trillions of microorganisms and houses the largest pool of macrophages in the human body. Being a part of the innate immune system, the macrophages, the professional phagocytes, vigorously respond to the microbial and dietary antigens present in the intestine. Because such a robust immune response poses the danger to the survival of the non-harmful and beneficial gut microbiota, the macrophages developed mechanisms of recognition and hyposensitivity toward the non-harmful/beneficial inhabitants of the gut. We will discuss the evolution and identity of some of these mechanisms in the following chapter.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Science and Business Media Deutschland GmbH
Pages605-616
Number of pages12
DOIs
StatePublished - 2020

Publication series

NameResults and Problems in Cell Differentiation
Volume69
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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