The lnterleukin-11 receptor a as a candidate ligand-directed target in osteosarcoma: Consistent data from cell lines, orthotopic models, and human tumor samples

Valerae O. Lewis, Michael G. Ozawa, Michael T. Deavers, Guiying Wang, Tomo Shintani, Wadih Arap, Renata Pasqualini

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The interleukin-11 receptor a (IL-IlRa) is a functional target in bone metastasis. However, its role in primary bone tumors has not been established. As such, here, we evaluated IL-IlRa as a candidate target in primary and metastatic human osteosarcoma. First, in an orthotopic mouse model, we showed that IL-IlRa protein is markedly expressed in primary osseus and pulmonary metastatic osteosarcoma but absent from control normal tibia and lung. Moreover, systemic administration of an IL-HRa-targeting phage displaying the cyclic nonapeptide CGRRAGGSC resulted in strong and selective accumulation of IL-HRa-homing phage particles in the osteosarcoma but not in several control organs. Finally, IL-HRa expression in a large panel of human primary and metastatic osteosarcoma samples was remarkably consistent with the observations in the orthotopic mouse model. These data establish IL-HRa as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor.

Original languageEnglish (US)
Pages (from-to)1995-1999
Number of pages5
JournalCancer research
Volume69
Issue number5
DOIs
StatePublished - Mar 1 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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