The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes

Shifu Aggarwal, Elaine Huang, Hackwon Do, Nishanth Makthal, Yanyan Li, Eric Bapteste, Philippe Lopez, Charles Bernard, Muthiah Kumaraswami

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The human pathogen Streptococcus pyogenes secretes a short peptide (leaderless communication peptide, LCP) that mediates intercellular communication and controls bacterial virulence through interaction with its receptor, RopB. Here, we show that LCP and RopB homologues are present in other Firmicutes. We experimentally validate that LCPs with distinct peptide communication codes act as bacterial intercellular signals and regulate gene expression in Streptococcus salivarius, Streptococcus porcinus, Enterococcus malodoratus and Limosilactobacillus reuteri. Our results indicate that LCPs are more widespread than previously thought, and their characterization may uncover new signaling mechanisms and roles in coordinating diverse bacterial traits.

Original languageEnglish (US)
Article number5947
Pages (from-to)5947
JournalNature Communications
Volume14
Issue number1
DOIs
StatePublished - Sep 23 2023

Keywords

  • Humans
  • Firmicutes
  • Quorum Sensing
  • Cell Communication
  • Peptides
  • Phenotype

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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