TY - JOUR
T1 - The Interplay of Race/Ethnicity and Obesity on the Incidence of Venous Thromboembolism
AU - Weze, Kelechi O.
AU - Obisesan, Olufunmilayo H.
AU - Dardari, Zeina A.
AU - Cainzos-Achirica, Miguel
AU - Dzaye, Omar
AU - Graham, Garth
AU - Miedema, Michael D.
AU - Yeboah, Joseph
AU - DeFilippis, Andrew P.
AU - Nasir, Khurram
AU - Blaha, Michael J.
AU - Osei, Albert D.
N1 - Funding Information:
This research was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by Grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences.
Funding Information:
The authors thank the other investigators, the staff, and the participants of the Multiethnic Study of Atherosclerosis (MESA) study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. This publication was developed under the Science to Achieve Results research assistance agreements, No. RD831697 (MESA Air) and RD-83830001 (MESA Air Next Stage), awarded by the U.S Environmental Protection Agency (EPA). It has not been formally reviewed by the EPA. The views expressed in this document are solely those of the authors, and the EPA does not endorse any products or commercial services mentioned in this publication. This research was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by Grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences. No financial disclosures were reported by the authors of this paper. Kelechi Weze: Conceptualization, Formal analysis, Methodology, Writing - original draft.Olufunmilayo H. Obisesan: Resources, Validation, Writing - review and editing. Zeina A. Dardari: Methodology, Formal analysis, Resources, Validation, Writing - review and editing. Miguel Cainzos-Achirica: Methodology, Resources, Validation, Writing - review and editing.Omar Dzaye: Visualization, Resources, Validation, Writing - review and editing. Garth Graham: Resources, Validation, Writing - review and editing. Michael D.Miedema: Resources, Validation, Writing - review and editing. Joseph Yeboah: Resources, Validation, Writing - review and editing. Andrew P. DeFilippis: Resources, Validation, Writing - review and editing. Khurram Nasir: Resources, Validation, Writing - review and editing. Michael J. Blaha: Conceptualization, Funding acquisition, Methodology, Supervision.Albert D. Osei: Conceptualization, Methodology.
Publisher Copyright:
© 2022 American Journal of Preventive Medicine
PY - 2022/7
Y1 - 2022/7
N2 - Introduction: Factors predisposing asymptomatic individuals within the community to venous thromboembolism are not fully understood. This study characterizes the incidence and determinants of venous thromboembolism among the Multiethnic Study of Atherosclerosis cohort with a focus on race/ethnicity and obesity. Methods: This study (analyzed in 2020–2021) used the Multiethnic Study of Atherosclerosis cohort (2000–2017), which included participants with diverse ethnic/racial backgrounds aged 45–84 years without cardiovascular disease at baseline. The primary endpoint was time to diagnosis of venous thromboembolism defined using International Classification of Diseases codes (415, 451, 453, 126, 180, and 182). Multivariable-adjusted hazard ratios of the predictors of venous thromboembolism were calculated with a focus on the interaction between obesity and race/ethnicity categories. Results: Over a median follow-up period of 14 years, 233 individuals developed venous thromboembolism. Incidence rates (per 1,000 person-years) varied across racial/ethnic groups with the highest incidence among Black (4.02) followed by White (2.98), Hispanic (2.08), and Chinese (0.79) participants. There was a stepwise increase in the incidence rate of venous thromboembolism with increasing BMI regardless of race/ethnicity: normal (1.95), overweight (2.52), obese (3.63), and morbidly obese (4.55). The association between BMI and venous thromboembolism was strongest among non-White women with the highest incidence rate for obese (4.8) compared with non-obese (1.6). The interaction among obesity, gender, and race was statistically significant (p=0.01) in non-White obese women. Risk of venous thromboembolism increased with age for all race/ethnicities. Conclusions: This study finds that obesity may confer an increased risk for venous thromboembolism among non-White women compared with other groups—White men, White women, and non-White men.
AB - Introduction: Factors predisposing asymptomatic individuals within the community to venous thromboembolism are not fully understood. This study characterizes the incidence and determinants of venous thromboembolism among the Multiethnic Study of Atherosclerosis cohort with a focus on race/ethnicity and obesity. Methods: This study (analyzed in 2020–2021) used the Multiethnic Study of Atherosclerosis cohort (2000–2017), which included participants with diverse ethnic/racial backgrounds aged 45–84 years without cardiovascular disease at baseline. The primary endpoint was time to diagnosis of venous thromboembolism defined using International Classification of Diseases codes (415, 451, 453, 126, 180, and 182). Multivariable-adjusted hazard ratios of the predictors of venous thromboembolism were calculated with a focus on the interaction between obesity and race/ethnicity categories. Results: Over a median follow-up period of 14 years, 233 individuals developed venous thromboembolism. Incidence rates (per 1,000 person-years) varied across racial/ethnic groups with the highest incidence among Black (4.02) followed by White (2.98), Hispanic (2.08), and Chinese (0.79) participants. There was a stepwise increase in the incidence rate of venous thromboembolism with increasing BMI regardless of race/ethnicity: normal (1.95), overweight (2.52), obese (3.63), and morbidly obese (4.55). The association between BMI and venous thromboembolism was strongest among non-White women with the highest incidence rate for obese (4.8) compared with non-obese (1.6). The interaction among obesity, gender, and race was statistically significant (p=0.01) in non-White obese women. Risk of venous thromboembolism increased with age for all race/ethnicities. Conclusions: This study finds that obesity may confer an increased risk for venous thromboembolism among non-White women compared with other groups—White men, White women, and non-White men.
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U2 - 10.1016/j.amepre.2021.12.023
DO - 10.1016/j.amepre.2021.12.023
M3 - Article
C2 - 35260291
AN - SCOPUS:85125719319
VL - 63
SP - e11-e20
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
SN - 0749-3797
IS - 1
ER -