The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7

M. A. Pritchard, E. Baker, S. A. Whitmore, G. R. Sutherland, R. L. Idzerda, L. S. Park, D. Cosman, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, M. P. Beckmann

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The chromosomal location of both the human and the mouse interleukin-4 receptor (IL4R) genes have been determined. The human gene was localized to 16p11.2-16p12.1 by in situ hybridization and confirmed by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines. The mouse homolog was positioned in the distal region of chromosome 7 by interspecific backcross analysis. The results suggest that the IL4R locus is unlinked to other members of the hematopoietin receptor family. Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas.

Original languageEnglish (US)
Pages (from-to)801-806
Number of pages6
JournalGenomics
Volume10
Issue number3
DOIs
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Genetics

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