TY - JOUR
T1 - The IntelliCage System
T2 - A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder
AU - Iman, Ismail Nurul
AU - Yusof, Nurul Aiman Mohd
AU - Talib, Ummi Nasrah
AU - Ahmad, Nur Aimi Zawami
AU - Norazit, Anwar
AU - Kumar, Jaya
AU - Mehat, Muhammad Zulfadli
AU - Jayabalan, Nanthini
AU - Muthuraju, Sangu
AU - Stefaniuk, Marzena
AU - Kaczmarek, Leszek
AU - Muzaimi, Mustapha
N1 - Funding Information:
This work was part of the research supported by Universiti Sains Malaysia (USM) Short Term Research grant (304/PPSP/6315252) and Research University grant (1001/PPSP/8012300) schemes awarded to MMu and NY. JK was supported by Universiti Kebangsaan Malaysia (UKM) Dana Fundamental (FF-2019-098) and MS was supported by a National Science Centre grant (2019/35/B/NZ4/04077).
Funding Information:
II holds a scholarship from the Public Service Department of Malaysia. Funding. This work was part of the research supported by Universiti Sains Malaysia (USM) Short Term Research grant (304/PPSP/6315252) and Research University grant (1001/PPSP/8012300) schemes awarded to MMu and NY. JK was supported by Universiti Kebangsaan Malaysia (UKM) Dana Fundamental (FF-2019-098) and MS was supported by a National Science Centre grant (2019/35/B/NZ4/04077).
Publisher Copyright:
© Copyright © 2021 Iman, Yusof, Talib, Ahmad, Norazit, Kumar, Mehat, Jayabalan, Muthuraju, Stefaniuk, Kaczmarek and Muzaimi.
PY - 2021/6/4
Y1 - 2021/6/4
N2 - The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
AB - The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
KW - addiction
KW - behavior
KW - home cage
KW - IntelliCage system
KW - rodent model
KW - substance use disorder (SUD)
UR - http://www.scopus.com/inward/record.url?scp=85108152686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108152686&partnerID=8YFLogxK
U2 - 10.3389/fnbeh.2021.683780
DO - 10.3389/fnbeh.2021.683780
M3 - Review article
AN - SCOPUS:85108152686
SN - 1662-5153
VL - 15
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
M1 - 683780
ER -