The influence of long-term nifedipine or indomethacin therapy on neurologic recovery from experimental spinal cord injury

Richard K. Simpson, David S. Baskin, Alden W. Dudley, Linda Bogue, Florence Rothenberg

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Inhibition of prostaglandin pathways and calcium channel conduction has been shown to improve neurological outcome after spinal cord injury. Functional recovery from such intervention has been routinely evaluated by a simple motor examination or somatosensory evoked potentials (SSEPs) after short-term drug administration. We comprehensively evaluated the influence of continuously administered indomethacin and nifedipine on functional outcome after impact spinal cord injury. SSEP and corticomotor evoked potential records and neurologic examinations were obtained over 6 weeks after injury. Terminal histopathologic changes within the spinal cord were also examined. Only indomethacin significantly improved neurological function and reduced the severity of histopathologic change. Evoked potential analysis was not found to be of prognostic value. Modulation of prostaglandin pathways may enhance neurological recovery after spinal cord injury.

Original languageEnglish (US)
Pages (from-to)420-427
Number of pages8
JournalJournal of Spinal Disorders
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1991

Keywords

  • Evoked potentials
  • Indomethacin
  • Nifedipine
  • Spinal cord injury

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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