The influence of heparin on the in vivo distribution of IN-111 labeled platelets

S. S. Zoghbi, M. L. Thakur, Henry Dirk Sostman, R. D. Neumann, P. Carbo, P. Lord, R. H. Greenspan, A. Gottschalk

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We investigated the influence of heparin (H) (bolus i.v.; 100-200 I.U./kg.) on the in vivo distribution and accumulation of autologous indium-111-platelets (In-111-P) on experimental pulmonary emboli (PE) in a canine model. Using a thrombin clot formation technique, we induced pulmonary emboli in ten dogs; three dogs were treated with heparin (H), and seven were not (NH). Of five control animals without PE, two were heparinized (H-control) and three were not (NH-control). Animals were sacrificed after 4 to 5 hours of serial blood sampling and sequential scintigrapy. We observed that heparin increased the recovery of In-111-P in the peripheral blood circulation of both control and PE dogs, and reduced the liver uptake of In-111-P in the PE dogs. No PE could be detected while the dogs were fully heparinized, but as the heparin effect dissipated over time, the deposition of In-111-P permitted the scintigraphic detection of PE.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalInvestigative Radiology
Volume20
Issue number2
DOIs
StatePublished - Jan 1 1985

Keywords

  • Heparin
  • IN-111 labeled platelets
  • Pulmonary embolism

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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