TY - JOUR
T1 - The incidence of HIV-1 and HHV-6 in corneal buttons
AU - Qavi, Hamida B.
AU - Green, Mary T.
AU - Segall, Gary K.
AU - Hollinger, F. Blaine
AU - Lewis, Dorothy E.
N1 - Funding Information:
ACKNOWLEDGEMENTS This work was supported by a grant from the National Eye Institute (EY08082). The corneas for this study were provided by the Lions Eyes of Texas Eye Bank. We thank Benny Tse and Ed Calomeni for excellent technical assistance. The authors are indebted to Ms. Caroyl Gilbert for typing this manuscript.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - Twenty pairs of corneas from asymptomatic carriers of HIV-1 and seven pairs from AIDS patients were analyzed for the presence of HIV-1 and HHV-6 antigens, viral transcripts, DNA sequences, and intact and infectious particles. Although serum from all donors was positive for both HIV-1 and HHV-6 antibody by Western blot analysis, only one cornea from an asymptomatic carrier of HIV-1 was positive for HIV-1 and HHV-6. The cornea was positive when tested by tissue culture, PCR, in situ hybridization, and electron microscopy. There was no tear film contamination. These results suggest that HIV-1 and HHV-6 may be capable of invading corneal tissue.
AB - Twenty pairs of corneas from asymptomatic carriers of HIV-1 and seven pairs from AIDS patients were analyzed for the presence of HIV-1 and HHV-6 antigens, viral transcripts, DNA sequences, and intact and infectious particles. Although serum from all donors was positive for both HIV-1 and HHV-6 antibody by Western blot analysis, only one cornea from an asymptomatic carrier of HIV-1 was positive for HIV-1 and HHV-6. The cornea was positive when tested by tissue culture, PCR, in situ hybridization, and electron microscopy. There was no tear film contamination. These results suggest that HIV-1 and HHV-6 may be capable of invading corneal tissue.
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U2 - 10.3109/02713689109020364
DO - 10.3109/02713689109020364
M3 - Article
C2 - 1650678
AN - SCOPUS:0025854101
VL - 10
SP - 97
EP - 103
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - s1
ER -