The incidence of HIV-1 and HHV-6 in corneal buttons

Hamida B. Qavi, Mary T. Green, Gary K. Segall, F. Blaine Hollinger, Dorothy E. Lewis

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Twenty pairs of corneas from asymptomatic carriers of HIV-1 and seven pairs from AIDS patients were analyzed for the presence of HIV-1 and HHV-6 antigens, viral transcripts, DNA sequences, and intact and infectious particles. Although serum from all donors was positive for both HIV-1 and HHV-6 antibody by Western blot analysis, only one cornea from an asymptomatic carrier of HIV-1 was positive for HIV-1 and HHV-6. The cornea was positive when tested by tissue culture, PCR, in situ hybridization, and electron microscopy. There was no tear film contamination. These results suggest that HIV-1 and HHV-6 may be capable of invading corneal tissue.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalCurrent Eye Research
Volume10
Issue numbers1
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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