The incidence of HIV-1 and HHV-6 in corneal buttons

Hamida B. Qavi, Mary T. Green, Gary K. Segall, F. Blaine Hollinger, Dorothy E. Lewis

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Twenty pairs of corneas from asymptomatic carriers of HIV-1 and seven pairs from AIDS patients were analyzed for the presence of HIV-1 and HHV-6 antigens, viral transcripts, DNA sequences, and intact and infectious particles. Although serum from all donors was positive for both HIV-1 and HHV-6 antibody by Western blot analysis, only one cornea from an asymptomatic carrier of HIV-1 was positive for HIV-1 and HHV-6. The cornea was positive when tested by tissue culture, PCR, in situ hybridization, and electron microscopy. There was no tear film contamination. These results suggest that HIV-1 and HHV-6 may be capable of invading corneal tissue.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalCurrent Eye Research
Issue numbers1
StatePublished - 1991

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'The incidence of HIV-1 and HHV-6 in corneal buttons'. Together they form a unique fingerprint.

Cite this