TY - JOUR
T1 - The incidence of HIV-1 and HHV-6 in corneal buttons
AU - Qavi, Hamida B.
AU - Green, Mary T.
AU - Segall, Gary K.
AU - Hollinger, F. Blaine
AU - Lewis, Dorothy E.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Twenty pairs of corneas from asymptomatic carriers of HIV-1 and seven pairs from AIDS patients were analyzed for the presence of HIV-1 and HHV-6 antigens, viral transcripts, DNA sequences, and intact and infectious particles. Although serum from all donors was positive for both HIV-1 and HHV-6 antibody by Western blot analysis, only one cornea from an asymptomatic carrier of HIV-1 was positive for HIV-1 and HHV-6. The cornea was positive when tested by tissue culture, PCR, in situ hybridization, and electron microscopy. There was no tear film contamination. These results suggest that HIV-1 and HHV-6 may be capable of invading corneal tissue.
AB - Twenty pairs of corneas from asymptomatic carriers of HIV-1 and seven pairs from AIDS patients were analyzed for the presence of HIV-1 and HHV-6 antigens, viral transcripts, DNA sequences, and intact and infectious particles. Although serum from all donors was positive for both HIV-1 and HHV-6 antibody by Western blot analysis, only one cornea from an asymptomatic carrier of HIV-1 was positive for HIV-1 and HHV-6. The cornea was positive when tested by tissue culture, PCR, in situ hybridization, and electron microscopy. There was no tear film contamination. These results suggest that HIV-1 and HHV-6 may be capable of invading corneal tissue.
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U2 - 10.3109/02713689109020364
DO - 10.3109/02713689109020364
M3 - Article
C2 - 1650678
AN - SCOPUS:0025854101
VL - 10
SP - 97
EP - 103
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - s1
ER -