The impact of sarcopenia on oncologic abdominal wall reconstruction

Chad M. Bailey, Mark V. Schaverien, Patrick B. Garvey, Jessie Liu, Charles E. Butler, Alexander F. Mericli

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background and Objectives: Sarcopenia is an objective measure of patient frailty and is a predictor of adverse surgical outcomes. We hypothesized that sarcopenia is associated with increased surgical site occurrence (SSO) and hernia occurrences in patients undergoing oncologic abdominal wall reconstruction. Methods: Consecutive patients who underwent abdominal wall reconstruction (AWR) for an abdominal wall ablative defect at a single center from 2005 to 2015 were evaluated. The total psoas index (TPI) was used to define sarcopenia. The primary endpoint of the study was hernia occurrence; (SSO) was a secondary outcome measure. Results: Eighty-six patients met the inclusion criteria. Multivariate analysis demonstrated that sarcopenia increased the risk of hernia more than threefold, trending toward significance (OR = 3.3; 95% CI: 0.69-15.4; P =.13). Multivariate logistic regression demonstrated that preoperative radiotherapy (OR = 4.8, 95% CI: 1.4-16; P =.01) and obesity (OR = 4.9, 95% CI: 1.5-16.3; P =.009) were independent predictors of developing an SSO. Conclusions: Sarcopenia, as defined by TPI, is correlated with hernia occurrence, but not SSO. These findings emphasize the importance of preoperative fitness and nutritional optimization and provide useful information for preoperative counseling and risk stratification.

Original languageEnglish (US)
Pages (from-to)1490-1497
Number of pages8
JournalJournal of Surgical Oncology
Volume122
Issue number7
DOIs
StatePublished - Dec 1 2020

Keywords

  • abdominal wall reconstruction
  • hernia
  • nutrition
  • sarcopenia
  • total psoas index

ASJC Scopus subject areas

  • Surgery
  • Oncology

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