The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer

Ciara E. O’Neill, Kai Sun, Sugunapriyadharshini Sundararaman, Jenny C. Chang, Sharon A. Glynn

Research output: Contribution to journalReview articlepeer-review

Abstract

The human epidermal growth factor receptor (HER) family consists of four members, activated by two families of ligands. They are known for mediating cell–cell interactions in organogenesis, and their deregulation has been associated with various cancers, including breast and esophageal cancers. In particular, aberrant epidermal growth factor receptor (EGFR) and HER2 signaling drive disease progression and result in poorer patient outcomes. Nitric oxide (NO) has been proposed as an alternative activator of the HER family and may play a role in this aberrant activation due to its ability to induce s-nitrosation and phosphorylation of the EGFR. This review discusses the potential impact of NO on HER family activation and downstream signaling, along with its role in the efficacy of therapeutics targeting the family.

Original languageEnglish (US)
Article number1358850
JournalFrontiers in Physiology
Volume15
DOIs
StatePublished - 2024

Keywords

  • cancer
  • epidermal growth factor receptor
  • human epidermal growth factor receptor 2
  • nitric oxide
  • nitrosation
  • post-translational modification

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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