The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery

Claudia Corbo, Roberto Molinaro, Alessandro Parodi, Naama E. Toledano Furman, Francesco Salvatore, Ennio Tasciotti

Research output: Contribution to journalReview article

260 Scopus citations

Abstract

In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue. The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner. However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC). This can trigger an immune response and affect NP toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the NP-PC interactions and discuss how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

Original languageEnglish (US)
Pages (from-to)81-100
Number of pages20
JournalNanomedicine
Volume11
Issue number1
DOIs
StatePublished - Jan 2016

Keywords

  • immune response
  • nano-bio interface
  • nanomedicine
  • nanoparticles
  • protein corona
  • targeting
  • toxicity

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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