The Impact of Frailty on Patients Undergoing Liver Resection for Colorectal Liver Metastasis

Jacqueline Dauch, Mohammad Hamidi, Amanda K. Arrington, Catherine L. O’Grady, Chiu Hsieh Hsu, Bellal Joseph, Taylor S. Riall, Mohammad Khreiss

Research output: Contribution to journalArticlepeer-review


Background: The aim of this study is to assess the impact of frailty on short-term outcomes after hepatectomy for colorectal liver metastasis (CRLM). Methods: Patients were identified using the National Surgical Quality Improvement Program (NSQIP). Patients were divided into 3 categories using the 5-item Modified Frailty Index (mFI). Results: There were 5230 patients included. 52%, 35%, and 13% had mFI scores of 0, 1, and ≥ 2 respectively. Patients with a ≥ 2 mFI score were more likely to experience minor complication (OR 1.34, 95% CI 1.06–1.69), major complication (OR 1.56, 95% CI 1.15–2.12), readmission (OR 1.55, 95% CI 1.12–2.14), unfavorable discharge (OR 2.48, 95% CI 1.62–3.80), 30-day mortality (OR 3.02, 95% CI 1.02–8.95), prolonged length of stay (OR 1.47, 95% CI 1.18–1.83), and bile leak (OR 1.51, 95% CI 1.02–2.24). Conclusion: Frailty is associated with increased post-operative complications. The 5-item mFI can guide risk stratification, optimization, and counseling.

Original languageEnglish (US)
Pages (from-to)608-614
Number of pages7
JournalJournal of Gastrointestinal Surgery
Issue number3
StatePublished - Mar 2022


  • Colorectal cancer
  • Frailty
  • Liver resection

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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